01 · How it works
Origins & Action
DMT activates serotonin 5-HT2A receptors and other targets including 5-HT1A, 5-HT2C, and sigma-1 systems. It is rapidly broken down by MAO-A when taken orally without an MAOI.
02 · Immediate effects
Recognize the effects
Signs of Use
- Dilated pupils and elevated heart rate
- Fractal visuals or vibrating sounds
- Sensory detachment and ego loss
- Motor immobility or sudden collapse
- Panic, sweating, or confusion
Short Term
- Immersive visual and auditory experiences
- Time distortion and altered identity
- Blood pressure and pulse elevation
- Nausea or vomiting with ayahuasca
- Acute fear or existential distress
Long Term
- Rare persistent visual disturbances
- Possible psychosis or mania in vulnerable people
- Derealization or depersonalization
- No typical physical dependence or withdrawal
03 · Long-term consequences
MAOI interaction hazard
Ayahuasca combines DMT with MAOIs, which can make it orally active and create dangerous interactions with serotonergic medications.
Medical emergency
Identifying an emergency
Clonus, high fever, seizures, hypertensive crisis, injury, or failure to regain consciousness require 911.
Danger: Serotonin syndrome risk with ayahuasca and serotonergic medications