Opioid education guide
A high-potency Schedule II opioid with a fast onset, rapid dependence risk, and severe respiratory-depression potential.
01 · Classification
A semi-synthetic hydrogenated ketone analog of morphine and potent full mu-opioid receptor agonist. It is approximately four to seven times more potent than morphine orally and up to ten times more potent parenterally.
02 · Acute effects
Therapeutic / low
Rapid analgesia, physical calming, mild somnolence, constricted pupils, mild hypotension, and dry mouth.
High / non-prescribed
An intense rush, heavy sedation, mental clouding, pinpoint pupils, nausea, itching, constipation, and urinary hesitancy.
Severe toxicity
Stupor, loss of consciousness, respiratory arrest, cyanosis, limp muscles, and hypothermia.
Medical emergency
Pinpoint pupils, profound unresponsiveness, slow or absent breathing, gurgling, blue or gray skin, or limp extremities require immediate help.
Dangerous combinations
Benzodiazepines, alcohol, xylazine, and medetomidine can intensify respiratory suppression, hypotension, bradycardia, and deep sedation.
Never mix opioids with other sedatives or use an unverified pill. Tell emergency responders what may have been taken.
03 · Long-term consequences
Dependence can develop quickly, with severe withdrawal often beginning within 12 to 24 hours after cessation.
A non-fatal overdose can cause hypoxic-anoxic encephalopathy, memory loss, tremors, and executive dysfunction.
Crushed tablets can introduce insoluble binders, increasing risks of pulmonary talcosis, endocarditis, and thrombosis.
Severe inhibition of peristalsis can cause painful fecal impaction and bowel perforation.
Verified resources
1-800-662-4357 · Free, confidential, 24/7 treatment referral and information.
For slow or absent breathing, loss of consciousness, or suspected overdose, call 911 immediately and use naloxone if available.