01 · How it works
Origins & Action
Mescaline is a substituted phenethylamine and partial agonist at 5-HT2A and 5-HT2C receptors with additional adrenergic activity. It has a delayed onset and can last 10 to 14 hours.
02 · Immediate effects
Recognize the effects
Signs of Use
- Dilated pupils and increased heart rate
- Color enhancement and visual drifting
- Nausea or vomiting during onset
- Tremors, sweating, or muscle tension
- Altered time and synesthesia
Short Term
- Geometric visuals and emotional processing
- Mild stimulant-like alertness
- Tachycardia and blood pressure elevation
- Prolonged sensory changes
- Panic or paranoia
Long Term
- Persistent visual disturbances
- Possible psychosis or mania in vulnerable people
- Rapid cross-tolerance with LSD and psilocybin
- No typical physical dependence or withdrawal
03 · Long-term consequences
Cardiovascular and psychiatric risk
The main dangers include prolonged vomiting, cardiovascular stress, dehydration, and acute psychological crisis.
Medical emergency
Identifying an emergency
Chest pain, irregular rhythm, hyperthermia, seizures, severe dehydration, or violent agitation require 911.
Critical: Lithium and classical psychedelics can increase seizure risk