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Substance education guide

Psilocybin

Tryptamine Psychedelic & 5-HT2A Agonist

Representative photo of PsilocybinWhat it looks like
Image: Robert van der Horst · CC BY-SA 4.0 · Wikimedia Commons. Appearance varies; illicit products may look different or be counterfeit.

01 · How it works

Origins & Action

Psilocybin is converted into psilocin, which acts on 5-HT2A receptors and temporarily reduces rigid self-referential processing, changing perception and perspective.

02 · Immediate effects

Recognize the effects

Signs of Use

  • Dilated pupils
  • Yawning, watery eyes, and runny nose
  • Uncontrollable laughter or crying
  • Visual surfaces that appear to move
  • Motor ataxia and disorientation
  • Altered time perception

Short Term

  • Geometric visual imagery
  • Synesthesia
  • Nausea during onset
  • Emotional catharsis
  • Ego-boundary dissolution
  • Acute anxiety or panic

Long Term

  • Increased openness
  • Possible reduction in depressive symptoms in clinical settings
  • Rare persistent visual disturbances
  • Possible psychosis precipitation in vulnerable people

03 · Long-term consequences

Foraging hazards

Confusing Psilocybe species with deadly amatoxin-containing mushrooms can cause fatal liver failure.

Medical emergency

Identifying an emergency

Acute panic, disorientation, terror, or dangerous confusion call for a quiet environment, calm communication, and emergency help when safety is at risk.

Danger: Severe seizures when combined with lithium
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